Diphenoxylate Hydrochloride
Diphenoxylate Hydrochloride is an opioid receptor agonist used to treat diarrhea by reducing intestinal motility and secretion. It is typically prescribed for acute and chronic diarrheal conditions when simpler anti-diarrheal measures are insufficient. Due to its potential for dependence, it is classified as a Schedule V controlled substance and is often formulated with small amounts of atropine to discourage misuse.
An anti-diarrheal medication that works by slowing gut motility through opioid receptor activation.
Key facts at a glance
- RxNorm
- 82005
- Generic
- Diphenoxylate Hydrochloride
- Class
- pin-variant
- Brands
- Lomotil
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute and chronic diarrhea, including traveler's diarrhea and diarrhea-predominant irritable bowel syndrome (IBS-D). Used when fluid and electrolyte replacement alone are inadequate for symptom control.
Acts as a mu-opioid receptor agonist in the gastrointestinal tract, reducing peristalsis, prolonging intestinal transit time, and decreasing intestinal secretions. This allows for more water absorption and firmer stools.
May cause drowsiness, dizziness, or sedation; avoid operating machinery. Has abuse and dependence potential despite low doses. Contraindicated in patients with obstructive jaundice, diarrhea associated with pseudomembranous colitis, or those taking CNS depressants. Not recommended for children under 6 years. Discontinue if abdominal distension develops.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy