Diphenylpyraline Hydrochloride
Diphenylpyraline Hydrochloride is a first-generation antihistamine medication used to treat allergic conditions such as hay fever, allergic rhinitis, and urticaria. It works by blocking histamine H1 receptors to reduce allergic symptoms like sneezing, itching, and runny nose, and is typically available in extended-release formulations.
First-generation antihistamine for treating allergies and allergic skin reactions.
Key facts at a glance
- RxNorm
- 203155
- Generic
- Diphenylpyraline Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats seasonal and perennial allergic rhinitis, urticaria, and other allergic conditions characterized by itching, sneezing, and rhinorrhea.
Acts as a competitive antagonist at peripheral H1 histamine receptors, blocking histamine-mediated allergic responses. As a first-generation antihistamine, it also possesses anticholinergic properties.
May cause drowsiness and impaired coordination; patients should avoid driving or operating machinery until they know how the medication affects them. Alcohol and other CNS depressants may intensify sedation. Use with caution in elderly patients due to anticholinergic effects. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy