Estradiol
Divigel is a topical estrogen replacement therapy used to treat moderate to severe symptoms of menopause in women. It delivers estradiol through the skin to help alleviate hot flashes, night sweats, and vaginal dryness associated with menopause.
Divigel is a hormone replacement gel used to treat menopause symptoms by delivering estrogen through the skin.
Key facts at a glance
- RxNorm
- 722259
- Generic
- Divigel
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Divigel is primarily used to treat moderate to severe vasomotor symptoms of menopause, including hot flashes and night sweats. It may also be used to prevent postmenopausal osteoporosis in women who cannot take other osteoporosis medications.
Divigel contains estradiol, a form of estrogen. When applied topically, the gel delivers estradiol through the skin into the bloodstream, supplementing the body's declining estrogen production during menopause and alleviating associated symptoms.
Divigel should not be used by women who are pregnant, breastfeeding, or have certain cancers, liver disease, or undiagnosed vaginal bleeding. Estrogen therapy carries risks including increased risk of stroke, blood clots, and certain cancers. It should be used at the lowest effective dose for the shortest duration consistent with treatment goals. The medication is for external use only and should be applied to clean, dry skin on the upper thigh.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy