Docosanol
Docosanol is a topical antiviral medication used to treat herpes simplex virus infections, commonly known as cold sores or fever blisters. It is applied directly to affected areas of the lips and face to reduce the duration and severity of symptoms. This medication is available over-the-counter for use in adults and children with recurrent cold sore outbreaks.
Docosanol is a topical antiviral cream used to treat cold sores by reducing their duration and severity.
Key facts at a glance
- ATC
- D06BB01
- RxNorm
- 197890
- Generic
- Docosanol
- Class
- atc-d06
- Brands
- Abreva
- Availability
- otc
- Pregnancy
- B
- Lactation
- safe
- Half-life (h)
- 0
- Onset (min)
- 0
- Duration (h)
- 0
- Routes
- topical
- Forms
- cream
- Regions
- United States, Canada
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Docosanol is used to treat recurrent herpes simplex labialis (cold sores or fever blisters) in adults and children 12 years and older. It is applied at the first sign of symptoms to help speed healing.
Docosanol works by inhibiting the fusion of the herpes simplex virus (HSV) with host cell membranes, thereby preventing viral entry into cells and reducing viral replication. This topical treatment acts locally at the site of application.
Apply a thin layer of docosanol cream to the affected area five times daily until the cold sore heals. Avoid applying near the eyes or inside the mouth. Wash hands before and after application. If symptoms do not improve within 10 days, consult a healthcare provider. This medication does not prevent transmission of herpes and is for external use only.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy