Dofetilide
Dofetilide is a Class III antiarrhythmic medication used to treat atrial fibrillation and atrial flutter. It works by blocking potassium channels in the heart, which helps maintain normal heart rhythm. Due to its potential to cause serious irregular heartbeats, it requires careful monitoring and in-hospital initiation.
A Class III antiarrhythmic medication for atrial fibrillation/flutter that works by blocking cardiac potassium channels.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- C01BD04
- RxNorm
- 49247
- Generic
- Dofetilide
- Class
- atc-c01
- Brands
- Tikosyn
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of highly symptomatic atrial fibrillation and atrial flutter to maintain normal sinus rhythm.
Blocks the rapid component of the delayed rectifier potassium current (IKr), prolonging the action potential duration and increasing the effective refractory period in cardiac tissue.
Must be initiated in a hospital setting with continuous cardiac monitoring due to risk of torsades de pointes. Requires dose adjustment based on kidney function and QT interval monitoring. Should not be used with drugs that prolong QT interval or inhibit renal cation transport.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy