Methadone
Dolophine is a brand-name opioid medication containing methadone, used for managing moderate to severe pain and as part of medication-assisted treatment for opioid use disorder. It works as a long-acting opioid agonist, binding to the same receptors as other opioids to reduce pain signals and prevent withdrawal symptoms.
Dolophine is an opioid medication used for pain relief and opioid addiction treatment, requiring careful medical supervision due to serious risks including respiratory depression and dependence.
Key facts at a glance
- RxNorm
- 202370
- Generic
- Dolophine
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dolophine is prescribed for the management of moderate to severe pain requiring continuous opioid therapy, and as an opioid agonist therapy (OAT) for treatment of opioid use disorder. It may also be used in detoxification programs for individuals dependent on other opioids.
As a long-acting full opioid agonist, Dolophine binds to mu-opioid receptors in the brain and nervous system, producing analgesic effects and preventing withdrawal symptoms in opioid-dependent individuals. Its effects last significantly longer than many other opioids, typically requiring once-daily dosing for pain management.
Due to risks of respiratory depression, cardiac arrhythmias (QT prolongation), and physical dependence, Dolophine should only be used under close medical supervision. It has a variable half-life and can accumulate in the body, increasing overdose risk. Patients should never adjust their dose without consulting their healthcare provider, and should inform all medical providers of their methadone use before any procedures.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy