Doravirine
Doravirine is an antiretroviral medication classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. It works by inhibiting the reverse transcriptase enzyme, which is essential for the virus to replicate. This medication is typically used as part of combination antiretroviral therapy in adults and pediatric patients.
Doravirine is an HIV medication that inhibits viral reverse transcriptase to prevent HIV-1 replication when used in combination with other antiretrovirals.
Key facts at a glance
- ATC
- J05AG06
- RxNorm
- 2055755
- Generic
- Doravirine
- Class
- atc-j05
- Brands
- Pifeltro, Delstrigo, Idvynso
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in combination with other antiretroviral agents. Used in adults and pediatric patients (weighing at least 35 kg). Available as monotherapy (Pifeltro) and in fixed-dose combinations (Delstrigo with lamivudine and tenofovir disoproxil fumarate).
Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by binding to HIV-1 reverse transcriptase and blocking the RNA-dependent and DNA-dependent polymerase activities, thereby preventing viral replication.
Should be used in combination with other antiretrovirals; not recommended as monotherapy except in the context of a switch regimen. May cause CNS effects such as dizziness and sleep disorders. Drug interactions with certain CYP3A4 inducers can reduce doravirine effectiveness. Resistance may develop if used inappropriately. Pregnancy category B; consult healthcare provider before use during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy