Dothiepin
Dothiepin is a tricyclic antidepressant (TCA) used primarily to treat major depressive disorder and anxiety-related conditions. It works by increasing the levels of certain neurotransmitters in the brain, specifically serotonin and norepinephrine, which help regulate mood and emotional state. While effective, it requires careful monitoring due to potential side effects and risks, particularly in certain populations.
A tricyclic antidepressant used to treat depression and anxiety by increasing serotonin and norepinephrine levels in the brain.
Key facts at a glance
- ATC
- N06AA16
- RxNorm
- 3634
- Generic
- Dothiepin
- Class
- atc-n06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of major depressive disorder, particularly cases with anxiety features. May also be used for neuropathic pain and insomnia in some healthcare systems.
Inhibits the reuptake of serotonin and norepinephrine in the brain, increasing their availability in synaptic clefts. Also has antagonist effects at certain receptors, contributing to its anxiolytic and sedative properties.
Requires dose titration; not recommended for patients with recent myocardial infarction, severe liver disease, or those taking MAOIs. Can cause sedation, dry mouth, constipation, urinary retention, weight gain, and cardiac conduction abnormalities. Highly dangerous in overdose. Should not be stopped abruptly.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy