Doxepin
Doxepin is a tricyclic antidepressant that is FDA-approved for treating depression, anxiety, and insomnia. At low doses, it is primarily used as a sleep aid for difficulty staying asleep, working through its antihistamine properties. At higher doses, it is prescribed for mood disorders.
Doxepin is an antihistamine and antidepressant used primarily for sleep maintenance and mood disorders.
Key facts at a glance
- ATC
- D04AX01
- RxNorm
- 3638
- Generic
- Doxepin
- Class
- atc-d04
- Brands
- Prudoxin, Silenor, Zonalon
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, topical
- Forms
- capsule, solution, tablet, cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Doxepin is indicated for the treatment of depression and anxiety at higher doses, and is FDA-approved as a sleep aid at low doses (3-6mg) for the treatment of insomnia characterized by difficulty staying asleep.
Doxepin works primarily through antagonism of H1 histamine receptors, which produces its sedative effects and helps maintain sleep. At higher doses, it also affects serotonin and norepinephrine reuptake to address mood symptoms.
Common side effects include drowsiness, dry mouth, and weight gain. Due to its anticholinergic properties, it should be used with caution in elderly patients. Alcohol and other CNS depressants may enhance sedation. Should not be discontinued abruptly.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy