Doxylamine Succinate
Doxylamine succinate is a first-generation antihistamine that provides relief from allergy symptoms such as runny nose, sneezing, and itchy eyes. It is commonly used as a sleep aid due to its sedative properties, helping individuals who experience difficulty falling asleep.
Doxylamine succinate is an antihistamine used for allergy relief and as a sleep aid.
Key facts at a glance
- RxNorm
- 23665
- Generic
- Doxylamine Succinate
- Class
- pin-variant
- Brands
- Diclegis, Wal-Som (doxylamine), Bonjesta, Unisom, Nocto, Zzzquil Ultra, Aldex AN
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats seasonal and perennial allergic symptoms including hay fever, allergic rhinitis, and cold symptoms such as runny nose and sneezing. Also used for short-term treatment of insomnia as a sleep aid.
Works by blocking histamine H1 receptors in the body, reducing allergic reactions. It also has anticholinergic properties and crosses the blood-brain barrier, producing sedation that aids sleep onset.
May cause drowsiness and impair alertness; avoid operating machinery or driving until aware of effects. Should not be used with alcohol or other CNS depressants. Not recommended for elderly patients due to anticholinergic risks. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy