Dronedarone
Dronedarone is an antiarrhythmic medication used to maintain normal heart rhythm in patients with atrial fibrillation or atrial flutter. It has properties of all four Vaughan-Williams antiarrhythmic classes, though its exact mechanism of action is not fully understood. This medication is typically prescribed after considering other treatment options due to its potential serious side effects.
Dronedarone is a multi-class antiarrhythmic used to control heart rhythm in atrial fibrillation and flutter.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- C01BD07
- RxNorm
- 233698
- Generic
- Dronedarone
- Class
- atc-c01
- Brands
- Multaq
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of atrial fibrillation and atrial flutter to reduce the risk of hospitalization and maintain normal sinus rhythm.
Exhibits antiarrhythmic properties across all four Vaughan-Williams classes (I, II, III, IV), including potassium channel blockade, beta-adrenergic blocking effects, and calcium channel blocking activity. The precise contribution of each property to its clinical effectiveness remains unknown.
Contraindicated in patients with severe heart failure (NYHA Class IV or recent decompensation), permanent atrial fibrillation, or significant liver impairment. Requires regular monitoring of liver function, renal function, and cardiac rhythm. Can cause QT prolongation, pulmonary toxicity, and hepatotoxicity. Should not be used in patients who cannot maintain sinus rhythm.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy