Drotrecogin Alfa
Drotrecogin Alfa (activated) is a recombinant form of human activated protein C that was used as an antithrombotic agent for the treatment of severe sepsis in adults with a high risk of death. The medication was administered as a continuous intravenous infusion and worked by providing anticoagulant, anti-inflammatory, and anti-apoptotic effects. Note: This drug was withdrawn from the market in 2011 due to lack of demonstrated survival benefit in clinical trials.
Drotrecogin Alfa was a recombinant protein C used for severe sepsis that has since been withdrawn from the market.
Key facts at a glance
- ATC
- B01AD10
- RxNorm
- 352374
- Generic
- Drotrecogin Alfa
- Class
- atc-b01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Severe sepsis (sepsis associated with acute organ dysfunction) in adults at high risk of death. It was specifically indicated for patients with APACHE II scores ≥25 or multiple organ failure.
As a recombinant form of activated protein C, it exerts anticoagulant effects by inhibiting factors Va and VIIIa. It also has anti-inflammatory properties, inhibits leukocyte activation, and promotes fibrinolysis, helping to reduce the dysregulated coagulation cascade seen in severe sepsis.
Withdrawn from market globally in 2011 (PROWESS-SHOCK trial showed no significant mortality benefit). Contraindicated in patients with active bleeding, recent stroke, or severe head trauma. Increased risk of bleeding complications during treatment. Required careful monitoring for bleeding events.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy