Ibuprofen and Famotidine
Duexis is a combination medication that pairs ibuprofen, an anti-inflammatory pain reliever, with famotidine, a stomach acid reducer. It is prescribed to manage pain and inflammation from osteoarthritis or rheumatoid arthritis while simultaneously helping to prevent stomach ulcers associated with NSAID use.
Duexis combines ibuprofen and famotidine to treat arthritis pain while protecting the stomach from NSAID-related ulcers.
Key facts at a glance
- RxNorm
- 1100067
- Generic
- Duexis
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Duexis is used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis, and to reduce the risk of developing NSAID-associated gastric ulcers in patients at risk of developing these complications.
Ibuprofen provides anti-inflammatory and analgesic effects by inhibiting cyclooxygenase (COX) enzymes, while famotidine reduces stomach acid production by blocking histamine H2 receptors, helping to prevent gastric ulcer formation that NSAIDs can cause.
Duexis carries the same risks as other NSAIDs, including increased risk of cardiovascular events, gastrointestinal bleeding, and kidney problems. Patients with a history of asthma, urticaria, or allergic reactions to aspirin should not use this medication. It should be used at the lowest effective dose for the shortest duration possible.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy