Atropine and Pralidoxime
Duodote is a combination medication containing atropine and pralidoxime, used as an emergency antidote for nerve agent or organophosphate pesticide poisoning. It counteracts the dangerous overstimulation of the nervous system caused by these toxic chemicals.
Duodote is an emergency antidote combining atropine and pralidoxime for nerve agent or organophosphate poisoning.
Key facts at a glance
- RxNorm
- 717229
- Generic
- Duodote
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Emergency treatment of nerve agent (sarin, VX, soman) or organophosphate pesticide poisoning in military, emergency, or toxicology settings where acetylcholinesterase inhibition is suspected.
Atropine blocks muscarinic receptors to reduce life-threatening secretions, bronchospasm, and bradycardia, while pralidoxime reactivates acetylcholinesterase enzyme to restore normal nerve signaling.
Must be administered as soon as possible after exposure; effectiveness decreases with delay. Typically given via auto-injector in emergency field settings. Medical supervision is critical as repeated dosing may be needed based on symptom severity.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy