Carbidopa and Levodopa
Duopa is a prescription medication for treating advanced Parkinson's disease in patients with severe motor fluctuations not adequately controlled by oral levodopa-carbidopa. It delivers levodopa and carbidopa continuously via intestinal infusion through a pump system, providing more stable blood levels of medication throughout the day and night.
Duopa is an intestinal infusion therapy for advanced Parkinson's disease that provides continuous levodopa-carbidopa delivery to reduce motor fluctuations and dyskinesias.
Key facts at a glance
- RxNorm
- 1599847
- Generic
- Duopa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of advanced Parkinson's disease in patients experiencing severe motor fluctuations (ON-OFF episodes) and dyskinesias that do not respond adequately to oral levodopa-carbidopa therapy.
Delivers levodopa and carbidopa directly into the jejunum (upper small intestine) via a portable pump, maintaining continuous 24-hour drug infusion to provide stable blood levels and more consistent symptom control compared to oral formulations.
Requires surgical placement of a temporary nasojejunal tube or permanent percutaneous endoscopic gastrojejunostomy (PEG-J) tube; should not be discontinued abruptly as this may cause neuroleptic malignant-like syndrome; common side effects include complications at the infusion site, nausea, and psychiatric symptoms such as hallucinations.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy