Edetate Calcium
Edetate Calcium, also known as Calcium EDTA, is a chelating agent used primarily to treat heavy metal poisoning, particularly lead toxicity. It works by binding to metal ions in the blood and tissues, forming a compound that can be excreted through the kidneys. This medication is administered intravenously in controlled clinical settings and is not available for oral use.
A chelating agent that removes toxic heavy metals like lead from the body, used primarily in cases of lead poisoning.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- RxNorm
- 1368950
- Generic
- Edetate Calcium
- Class
- unclassified
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- injection, cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute and chronic lead poisoning, including lead encephalopathy and lead-induced nephropathy. May also be used for other heavy metal toxicities in certain clinical situations.
As a chelating agent, Edetate Calcium binds to lead and other divalent/trivalent metal ions through its chemical structure, forming stable, water-soluble complexes that are eliminated primarily through renal excretion.
Must be administered by healthcare professionals in appropriate clinical settings. Requires adequate hydration and monitoring of renal function, blood pressure, and electrolytes. Contraindicated in patients with anuria, severe renal disease, or known hypersensitivity. May cause nephrotoxicity if not properly managed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy