Elafibranor
Elafibranor is a PPAR agonist under investigation for treating liver diseases like primary biliary cholangitis and non-alcoholic steatohepatitis.
Elafibranor is an experimental PPAR agonist being developed to treat liver diseases like PBC and NASH by targeting lipid and glucose metabolism pathways.
Key facts at a glance
- ATC
- A05AX06
- RxNorm
- 2684941
- Generic
- Elafibranor
- Class
- atc-a05
- Brands
- Iqirvo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Elafibranor is primarily being investigated for primary biliary cholangitis (PBC), a chronic autoimmune liver disease, and non-alcoholic steatohepatitis (NASH), a severe form of fatty liver disease. It was previously studied for metabolic disorders including type 2 diabetes and dyslipidemia.
Elafibranor activates PPAR-alpha, PPAR-gamma, and PPAR-delta receptors. This multi-receptor activation helps reduce liver inflammation, improve insulin sensitivity, decrease lipid accumulation in the liver, and enhance bile flow. The main active metabolite, GFT1007, also contributes to the therapeutic effects.
Elafibranor is an investigational drug not yet approved by regulatory authorities. Clinical trials have shown it can improve liver biochemistry markers in PBC and NASH patients. Common side effects in trials included mild gastrointestinal symptoms. As a PPAR agonist, it may affect lipid levels and requires monitoring of liver function tests during treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy