Elinzanetant
Elinzanetant is a dual neurokinin 1 (NK1) and neurokinin 3 (NK3) receptor antagonist used to treat moderate to severe hot flashes associated with menopause. It works by modulating thermoregulatory pathways in the hypothalamus. As a non-hormonal treatment option, it offers an alternative for women who cannot or prefer not to use hormone therapy.
Elinzanetant is a non-hormonal medication that reduces menopausal hot flashes by blocking neurokinin receptors involved in the body's temperature regulation.
Key facts at a glance
- ATC
- G02CX07
- RxNorm
- 2725511
- Generic
- Elinzanetant
- Class
- atc-g02
- Brands
- Lynkuet
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause
Blocks NK1 and NK3 receptors on kisspeptin/neurokinin B/dynorphin (KNDy) neurons, inhibiting Substance P and Neurokinin B signaling to modulate thermoregulatory activity and reduce hot flash frequency and severity
Non-hormonal alternative for women who cannot use hormone therapy. May cause side effects including fatigue, headache, or abnormal liver function tests. Patients should discuss full medical history with their healthcare provider before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy