Eluxadoline
Eluxadoline is a mixed opioid receptor modulator used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults by targeting mu, kappa, and delta opioid receptors in the gastrointestinal tract.
A gut-directed opioid medication for treating IBS-D that reduces diarrhea and abdominal pain by modulating opioid receptors in the intestines.
Key facts at a glance
- ATC
- A07DA06
- RxNorm
- 1653781
- Generic
- Eluxadoline
- Class
- atc-a07
- Brands
- Viberzi
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Eluxadoline is FDA-approved for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adult patients.
Eluxadoline acts as a mu-opioid receptor agonist and kappa-opioid receptor agonist while simultaneously antagonizing delta-opioid receptors. This mixed opioid receptor activity in the gastrointestinal tract reduces intestinal motility, decreases fluid secretion, and modulates pain signals, resulting in reduced diarrhea and abdominal discomfort.
Contraindicated in patients without a gallbladder, those with known or suspected biliary duct obstruction, gallbladder disease, severe hepatic impairment, or history of pancreatitis. Can cause serious adverse effects including sphincter of Oddi spasm and pancreatitis. Common side effects include constipation, nausea, and abdominal pain. Patients should be monitored appropriately during treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy