Aprepitant
Emend (aprepitant) is a prescription antiemetic medication used to prevent nausea and vomiting associated with chemotherapy and surgery. It belongs to the neurokinin-1 (NK1) receptor antagonist class of drugs and is typically used in combination with other anti-nausea medications for optimal effectiveness.
Emend is a prescription anti-nausea medication used to prevent chemotherapy-induced and post-operative vomiting.
Key facts at a glance
- RxNorm
- 357280
- Generic
- Emend
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevents acute and delayed nausea and vomiting associated with chemotherapy (particularly highly emetogenic chemotherapy regimens) and prevents post-operative nausea and vomiting in adults.
Blocks substance P at NK1 receptors in the brain's vomiting center, targeting a different pathway than standard antiemetics (like 5-HT3 antagonists or corticosteroids), allowing for complementary anti-nausea effects when used together.
Available as oral capsules; a related injectable form (fosaprepitant) may be used on the day of chemotherapy. May interact with certain medications metabolized by CYP3A4 enzymes. Common side effects include fatigue, hiccups, and elevated liver enzymes. Not for treating existing nausea/vomiting—only for prevention.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy