Pegcetacoplan
Empaveli is a prescription medication used to treat paroxysmal nocturnal hemoglobinuria (PNH) in adults. It works as a complement inhibitor, targeting the C3 protein to help reduce red blood cell destruction associated with this rare blood disorder. This medication is administered as a subcutaneous infusion.
Empaveli is a complement inhibitor used to treat the rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH) in adults.
Key facts at a glance
- RxNorm
- 2557387
- Generic
- Empaveli
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Empaveli is FDA-approved for the treatment of adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired blood disorder characterized by the destruction of red blood cells, potentially leading to anemia, blood clots, and other complications.
Empaveli is a complement inhibitor that works by targeting complement protein C3, which plays a key role in the immune system's complement pathway. By inhibiting C3, it helps prevent the breakdown of red blood cells in PNH.
Empaveli is administered via subcutaneous infusion. Patients should be monitored for infections, particularly meningococcal infections, as complement inhibitors may increase susceptibility. It should not be used in patients with active infections caused by encapsulated bacteria. Common side effects may include injection site reactions, upper respiratory infections, and gastrointestinal symptoms. Patients should be vaccinated against encapsulated bacteria before starting treatment. This is a brand-name medication with no generic equivalent currently available.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy