Encorafenib
Encorafenib is a targeted cancer medication that inhibits BRAF kinases, including the mutated V600E form that drives certain melanomas and other cancers. It is typically used in combination with other agents like binimetinib for patients whose tumors have BRAF V600E or V600K mutations. By blocking these abnormal signals, it helps slow or stop cancer cell growth.
Encorafenib is a BRAF inhibitor used to treat melanoma and other cancers with BRAF mutations.
Key facts at a glance
- ATC
- L01EC03
- RxNorm
- 2049106
- Generic
- Encorafenib
- Class
- atc-l01
- Brands
- Braftovi
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Encorafenib is approved for treating unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and may be used in combination with binimetinib (a MEK inhibitor) or other agents. It may also be used for other BRAF-mutated cancers as determined by a healthcare provider.
Encorafenib inhibits BRAF kinases that have specific mutations (V600E, V600K) which cause continuous, uncontrolled cell signaling that promotes cancer growth. By blocking these mutated kinases, it interrupts the signaling pathways that cancer cells depend on for survival and proliferation.
Encorafenib is prescribed based on confirmed BRAF mutation testing and should only be used under oncologist supervision. Common side effects may include fatigue, nausea, joint pain, and skin reactions. Patients should avoid pregnancy during treatment and report any unusual bleeding, fever, or vision changes to their healthcare team.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy