L-Glutamine
Endari (L-glutamine) is a brand-name amino acid powder used to reduce acute complications in patients with sickle cell disease. It is FDA-approved for use in adults and children 5 years and older. The medication is taken orally, typically twice daily with or without food.
Endari is an amino acid supplement used to manage acute complications of sickle cell disease in patients 5 years and older.
Key facts at a glance
- RxNorm
- 1928936
- Generic
- Endari
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Endari is indicated to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older. It helps decrease the frequency of painful crises and hospitalizations related to the condition.
As an amino acid, L-glutamine serves as a fuel source for cells and may help reduce oxidative stress. In sickle cell disease, glutamine supplementation is believed to improve the metabolic function of red blood cells, potentially reducing hemolysis and the adhesion of sickled cells to blood vessel walls.
Endari is a prescription medication available as an oral powder. Patients should follow dosing instructions carefully, typically taking it twice daily. Common side effects may include constipation, nausea, headache, and abdominal pain. Patients should inform their healthcare provider of all medications and supplements they are taking before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy