Enfuvirtide
Enfuvirtide is an antiretroviral medication classified as a fusion inhibitor, used in the treatment of HIV-1 infection. It is typically prescribed for treatment-experienced patients who have failed other antiretroviral regimens, helping to reduce viral load and improve immune function when combined with other HIV medications.
Enfuvirtide is a fusion inhibitor injection used to treat HIV-1 in patients who have not responded to other antiretroviral therapies.
Key facts at a glance
- ATC
- J05AX07
- RxNorm
- 139896
- Generic
- Enfuvirtide
- Class
- atc-j05
- Brands
- Fuzeon
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Enfuvirtide is indicated for the treatment of HIV-1 infection in treatment-experienced adults and children aged 6 years and older who have demonstrated evidence of viral replication despite ongoing antiretroviral therapy. It is always used in combination with other antiretroviral medications.
Enfuvirtide is a fusion inhibitor that works by binding to the gp41 subunit of the HIV-1 viral envelope glycoprotein, preventing the conformational changes required for viral fusion with host CD4+ T-cell membranes. This blocks viral entry into the cell, inhibiting the replication cycle of HIV.
Enfuvirtide is administered as a subcutaneous injection, typically twice daily. Common side effects include injection site reactions (pain, nodules, inflammation), and bacterial pneumonia has been observed in some patients. It should not be used as monotherapy and must be combined with other active antiretrovirals to prevent viral resistance.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy