Trastuzumab Deruxtecan
Enhertu (trastuzumab deruxtecan) is a HER2-directed antibody-drug conjugate used to treat certain HER2-positive or HER2-low cancers. It works by targeting HER2 proteins on cancer cells and delivering a potent chemotherapy agent directly to tumor cells, while sparing many healthy cells.
Enhertu is a targeted cancer therapy for HER2-positive or HER2-low breast, gastric, and lung cancers that delivers chemotherapy directly to tumor cells.
Key facts at a glance
- RxNorm
- 2267577
- Generic
- Enhertu
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats HER2-positive metastatic breast cancer, HER2-low breast cancer, HER2-positive gastric or gastroesophageal junction adenocarcinoma, and HER2-mutant non-small cell lung cancer (NSCLC). Treatment is typically considered after prior chemotherapy regimens.
Enhertu is an antibody-drug conjugate consisting of a HER2-targeting monoclonal antibody linked to a cytotoxic agent (deruxtecan). The antibody binds to HER2 on cancer cells, allowing the drug to enter and release its chemotherapy payload inside the tumor, causing DNA damage and cell death.
Administered as an intravenous infusion every 3 weeks. Carries a boxed warning for interstitial lung disease (ILD) and embryo-fetal toxicity. May cause neutropenia, nausea, and fatigue. Requires monitoring for lung symptoms and pregnancy prevention during and for 7 months after treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy