Ensifentrine
Ensifentrine is a dual phosphodiesterase 3 and 4 (PDE3/PDE4) inhibitor used as a maintenance bronchodilator for chronic obstructive pulmonary disease (COPD). By inhibiting PDE3 and PDE4 enzymes, it prevents the breakdown of cyclic adenosine monophosphate (cAMP), leading to smooth muscle relaxation in the airways and improved breathing.
A dual PDE3/PDE4 inhibitor bronchodilator delivered via nebulization for COPD maintenance treatment.
Key facts at a glance
- ATC
- R03BX02
- RxNorm
- 2687215
- Generic
- Ensifentrine
- Class
- atc-r03
- Brands
- Ohtuvayre
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Maintenance treatment of chronic obstructive pulmonary disease (COPD) to improve lung function and reduce exacerbations.
Ensifentrine inhibits both PDE3 and PDE4 enzymes, which are responsible for breaking down cyclic adenosine monophosphate (cAMP). Elevated cAMP levels promote bronchodilation by relaxing airway smooth muscle, reducing inflammation, and improving mucociliary clearance.
Administered via nebulizer, making it suitable for patients who may have difficulty using traditional inhalers. As a small molecule agent, it offers a dual mechanism targeting both bronchodilation and anti-inflammatory pathways. Patients should follow their healthcare provider's instructions regarding dosing frequency and technique.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy