Epclusa
Epclusa is a prescription antiviral medication used to treat chronic Hepatitis C virus (HCV) infection in adults. It contains a combination of two direct-acting antiviral agents that work together to inhibit virus replication. This medication is notable for being effective against multiple genotypes (1-6) of the Hepatitis C virus.
Epclusa is a brand-name antiviral combination medication used to treat chronic Hepatitis C virus infection in adults.
Key facts at a glance
- RxNorm
- 1799213
- Generic
- Epclusa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic Hepatitis C virus (HCV) infection in adults, including those with compensated cirrhosis. Effective across multiple HCV genotypes (1, 2, 3, 4, 5, and 6). May be used in patients co-infected with HIV.
Epclusa combines sofosbuvir and velpatasvir, two direct-acting antiviral agents. Sofosbuvir is a nucleotide analog inhibitor that blocks the NS5B RNA-dependent RNA polymerase, while velpatasvir is an NS5A inhibitor that prevents virus replication and assembly.
Typically taken once daily for 12 weeks with or without food. May interact with certain medications including anticonvulsants, rifampin, and some HIV drugs. Common side effects may include headache, fatigue, and nausea. Patients should be monitored for hepatitis B reactivation before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy