Epinastine
Epinastine is a topical antihistamine medication primarily used as eye drops to treat allergic conjunctivitis. It works by blocking histamine H1 receptors and preventing histamine release from mast cells, providing relief from eye itching, redness, and irritation caused by allergies.
Epinastine is a topical antihistamine eye drop that relieves allergic eye symptoms by blocking histamine receptors and preventing mast cell histamine release.
Key facts at a glance
- ATC
- R06AX24
- RxNorm
- 39684
- Generic
- Epinastine
- Class
- atc-r06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- ophthalmic
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of allergic conjunctivitis and relief of associated eye symptoms including itching, redness, swelling, and irritation caused by environmental allergens.
Epinastine is a selective, direct H1-receptor antagonist with some affinity for H2-receptors. It also inhibits the release of histamine from mast cells, preventing allergic inflammatory responses in the eyes.
For topical ophthalmic use only. Patients should wash hands before application and avoid touching the dropper tip. Contact lens removal may be required depending on formulation. May cause mild, transient eye discomfort or burning upon instillation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy