Eplerenone
Eplerenone is a mineralocorticoid receptor antagonist used primarily to treat heart failure after heart attack and high blood pressure. By blocking aldosterone, it helps reduce fluid retention and lowers blood pressure while preserving potassium levels.
A potassium-sparing diuretic that treats heart failure and hypertension by blocking aldosterone's effects on the kidneys.
Key facts at a glance
- ATC
- C03DA04
- RxNorm
- 298869
- Generic
- Eplerenone
- Class
- atc-c03
- Brands
- Inspra
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Eplerenone is used to treat heart failure (particularly after myocardial infarction) and essential hypertension. It is often prescribed when other blood pressure medications are insufficient or in combination with other heart failure therapies.
Eplerenone selectively binds to mineralocorticoid receptors in the kidneys, blocking aldosterone from binding. This prevents aldosterone-mediated sodium and water reabsorption, reducing blood volume and blood pressure while retaining potassium.
Regular monitoring of potassium levels and kidney function is essential, as hyperkalemia is a risk. Eplerenone is contraindicated in patients with severe kidney impairment, type 2 diabetes with proteinuria, or those taking potassium-sparing diuretics or ACE inhibitors. Side effects may include dizziness, fatigue, and elevated potassium.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy