Epoprostenol
Epoprostenol is a synthetic prostacyclin that acts as a potent vasodilator and platelet aggregation inhibitor. It is primarily used to treat pulmonary arterial hypertension (PAH) by dilating blood vessels in the lungs, reducing pulmonary vascular resistance, and improving blood flow. The medication is administered as a continuous intravenous infusion due to its short half-life.
Epoprostenol is a prostacyclin used to treat pulmonary arterial hypertension by dilating lung blood vessels and preventing blood clots.
Key facts at a glance
- ATC
- B01AC09
- RxNorm
- 8814
- Generic
- Epoprostenol
- Class
- atc-b01
- Brands
- Veletri, Flolan
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primary treatment for pulmonary arterial hypertension (PAH), including in patients with NYHA Class III-IV symptoms. May also be used for other forms of pulmonary hypertension and in certain cardiac conditions.
Acts as a prostacyclin (PGI2) analog that directly dilates pulmonary and systemic arterial vascular beds, reducing pulmonary vascular resistance and blood pressure. Also inhibits platelet aggregation by increasing cAMP in platelets, preventing thrombus formation.
Administered via continuous IV infusion using a specialized pump due to very short half-life (approximately 3-5 minutes). Requires careful dose titration under medical supervision. Common side effects include flushing, headache, hypotension, jaw pain, and nausea. Abrupt discontinuation should be avoided as it may cause worsening of pulmonary hypertension. Patients require training on pump operation and infusion site care.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy