Erdafitinib
Erdafitinib is a targeted cancer medication that inhibits fibroblast growth factor receptors (FGFR1-4), which are involved in cancer cell growth and proliferation. It is specifically approved for treating adults with locally advanced or metastatic urothelial carcinoma (bladder cancer) that has certain FGFR genetic alterations and has progressed after platinum-based chemotherapy.
A targeted therapy for FGFR-altered advanced bladder cancer that works by blocking specific growth factor receptors on cancer cells.
Key facts at a glance
- ATC
- L01EN01
- RxNorm
- 2123125
- Generic
- Erdafitinib
- Class
- atc-l01
- Brands
- Balversa
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Erdafitinib is indicated for the treatment of adults with locally advanced or metastatic urothelial carcinoma that has FGFR3 or FGFR2 genetic alterations and has progressed during or after at least one prior platinum-containing chemotherapy regimen.
Erdafitinib is a tyrosine kinase inhibitor that binds to and inhibits FGFR1, FGFR2, FGFR3, and FGFR4. By blocking these receptors, it inhibits FGFR phosphorylation and downstream signaling pathways, which decreases cancer cell viability and proliferation in tumors with FGFR genetic alterations.
Erdafitinib is taken orally once daily. Common side effects include phosphate elevation, stomatitis, fatigue, and skin-related reactions. Eye exams are recommended at baseline and periodically during treatment due to risk of ocular disorders. Patients should avoid pregnancy during treatment as it can cause fetal harm.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy