Estetrol
Estetrol is a naturally occurring estrogen hormone used in combined hormonal contraceptives (CHCs). It works by suppressing ovulation to prevent pregnancy. As an estrogen component in birth control formulations, it helps regulate the menstrual cycle and complements progestin in preventing conception.
Estetrol is an estrogen hormone used in combined hormonal contraceptives to prevent pregnancy by suppressing ovulation.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G03CA10
- RxNorm
- 2539031
- Generic
- Estetrol
- Class
- atc-g03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of pregnancy when used as part of combined hormonal contraceptives (CHCs). May also be used in menopausal hormone therapy and other estrogen-related applications.
Estetrol suppresses ovulation by inhibiting the release of gonadotropins (FSH and LH) from the pituitary gland. As an estrogen, it also contributes to thickening cervical mucus and altering the endometrium to further prevent conception.
Estetrol is a selective estrogen receptor modulator (SERM) with tissue-specific activity. It is typically combined with a progestin in contraceptive formulations. Use is contraindicated in patients with known or suspected breast cancer, undiagnosed vaginal bleeding, or known thromboembolic disorders. Like all hormonal contraceptives, it does not protect against sexually transmitted infections.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy