Estrace
Estrace (estradiol) is a form of estrogen hormone used to treat symptoms of menopause such as hot flashes, vaginal dryness, and osteoporosis prevention. It is also prescribed for women with ovarian failure or hypogonadism, and is sometimes used in palliative treatment of breast cancer. The medication works by replacing the estrogen that the body no longer produces adequately.
Estrace is an estrogen replacement medication used to treat menopause symptoms and hormone deficiencies in women.
Key facts at a glance
- RxNorm
- 202619
- Generic
- Estrace
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe vasomotor symptoms (hot flashes) and vulvovaginal atrophy associated with menopause; female hypogonadism; ovarian failure; palliative treatment of breast cancer; prevention of postmenopausal osteoporosis
Estradiol, the active ingredient in Estrace, is a synthetic form of the primary female sex hormone. It binds to estrogen receptors in target tissues including the hypothalamus, reproductive system, and bone, replacing declining endogenous estrogen to restore hormonal balance and alleviate menopausal symptoms.
Increases risk of endometrial cancer when used without a progestin in women with an intact uterus. Associated with increased risk of stroke, DVT, and pulmonary embolism. May increase risk of breast cancer with prolonged use. Contraindicated during pregnancy. Should be used at the lowest effective dose for the shortest duration consistent with treatment goals. Non-hormonal alternatives should be considered for osteoporosis prevention.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy