Estrogel
Estrogel is a topical estrogen replacement medication that delivers the hormone estradiol through the skin via a gel formulation. It is primarily prescribed to treat moderate to severe menopausal symptoms such as hot flashes and vaginal dryness in women. The transdermal delivery system allows for steady hormone absorption without passing through the liver first.
Estrogel is a topical estradiol gel used to relieve menopausal symptoms in women through transdermal hormone replacement therapy.
Key facts at a glance
- RxNorm
- 405052
- Generic
- Estrogel
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe vasomotor symptoms (hot flashes) associated with menopause, and prevention of postmenopausal osteoporosis. May also be used for vaginal atrophy symptoms.
Delivers synthetic estradiol directly through the skin into the bloodstream, supplementing declining estrogen levels during menopause and perimenopause.
Should be applied to clean, dry skin on the arm. Not for use during pregnancy. Discuss cardiovascular risks, breast cancer risk, and endometrial cancer risk with your healthcare provider. Avoid contact with others to prevent accidental exposure.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy