Estrone
Estrone is a naturally occurring estrogen hormone used primarily in hormone replacement therapy for women experiencing estrogen deficiency due to menopause, surgical removal of ovaries, or other conditions causing low hormone levels. It helps relieve menopausal symptoms and may be used to help prevent bone loss in postmenopausal women.
Estrone is an estrogen hormone replacement therapy used to treat estrogen deficiency symptoms in women.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G03C
- RxNorm
- unknown
- Generic
- Estrone
- Class
- atc-g03
- Brands
- —
- Availability
- otc
- Pregnancy
- X
- Lactation
- unsafe
- Half-life (h)
- 2
- Onset (min)
- 60
- Duration (h)
- 24
- Routes
- oral, topical, vaginal
- Forms
- tablet, cream, gel
- Regions
- United States, Canada, United Kingdom, Germany
- Monitoring
- cardiovascular events, venous thromboembolism, breast cancer risk, endometrial hyperplasia
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat symptoms of menopause such as hot flashes, vaginal dryness, and night sweats; also used in hormone replacement therapy after oophorectomy and to help prevent osteoporosis in postmenopausal women.
As an estrogen hormone, estrone binds to estrogen receptors in various target tissues throughout the body, producing effects similar to naturally occurring estrogen to regulate reproductive functions and maintain bone density.
Should not be used during pregnancy; carries risks including increased chance of blood clots, stroke, and certain cancers with long-term use; requires careful evaluation by a healthcare provider before starting therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy