Estrumate
Estrumate is a veterinary medication containing cloprostol, a synthetic prostaglandin F2α analogue. It is primarily used in cattle and other livestock for estrus synchronization, treatment of reproductive disorders such as pyometra, and induction of parturition or pregnancy termination when medically necessary.
Estrumate is a prostaglandin-based veterinary hormone used to manage reproduction in livestock, primarily cattle.
Key facts at a glance
- RxNorm
- 1495267
- Generic
- Estrumate
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Estrumate is indicated for estrus synchronization in cattle, treatment of cystic ovarian disease and pyometra, induction of parturition in late pregnancy, and termination of unwanted pregnancies in livestock.
As a prostaglandin F2α analogue, Estrumate induces luteolysis (breakdown of the corpus luteum) by causing regression of the yellow body on the ovary, which removes progesterone inhibition and allows estrus and ovulation to occur.
This medication is for veterinary use only and should be administered by or under the direction of a licensed veterinarian. It should not be used in pregnant animals unless termination is intended. Animals should be properly restrained during administration, and proper injection site protocols should be followed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy