Ethionamide
Ethionamide is a second-line antimycobacterial agent used in the treatment of tuberculosis, particularly for multidrug-resistant cases when first-line medications like isoniazid and rifampin cannot be used or are ineffective. It is always administered in combination with other antituberculosis drugs to prevent bacterial resistance and enhance treatment efficacy.
A second-line tuberculosis medication used for drug-resistant cases in combination with other antituberculosis drugs.
Key facts at a glance
- ATC
- J04AD03
- RxNorm
- 4127
- Generic
- Ethionamide
- Class
- atc-j04
- Brands
- Trecator
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of tuberculosis caused by Mycobacterium tuberculosis strains that are resistant to first-line medications. Primarily used for multidrug-resistant tuberculosis (MDR-TB) as part of combination therapy regimens.
Acts as a prodrug that inhibits mycolic acid synthesis, a critical component of the mycobacterial cell wall. By disrupting cell wall formation, it prevents bacterial replication and growth.
Must always be used in combination with other antituberculosis medications to prevent resistance. Associated with hepatotoxicity, gastrointestinal disturbances, and potential neurological or psychiatric side effects. Requires liver function monitoring during treatment. Not suitable as monotherapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy