Etrasimod
Etrasimod is an immunosuppressant medication that works as a sphingosine 1-phosphate (S1P) receptor modulator. It binds to specific S1P receptors (1, 4, and 5) to help regulate immune cell trafficking, reducing the inflammatory response. This medication is used to treat inflammatory conditions by preventing certain immune cells from migrating to sites of inflammation.
Etrasimod is an S1P receptor modulator used to treat inflammatory conditions by reducing immune cell migration to inflamed tissues.
Key facts at a glance
- ATC
- L04AE05
- RxNorm
- 2668045
- Generic
- Etrasimod
- Class
- atc-l04
- Brands
- Velsipity
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Etrasimod is used to treat inflammatory bowel diseases such as ulcerative colitis, and has shown efficacy in other autoimmune conditions where immune-mediated inflammation plays a key role.
Etrasimod selectively binds to S1P receptors 1, 4, and 5 with high affinity, while having minimal activity on S1P3 and no activity on S1P2. This modulates lymphocyte trafficking, preventing immune cells from exiting lymph nodes and reaching inflamed tissues, thereby reducing inflammatory responses.
As an S1P receptor modulator, etrasimod may affect heart rate and requires monitoring during initiation. Common side effects may include headache, elevated liver enzymes, and dizziness. Patients should be monitored for infections due to its immunosuppressive effects. Pregnancy testing and contraception may be recommended before and during treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy