Euflexxa
Euflexxa is a brand-name viscosupplement containing sodium hyaluronate, administered as an intra-articular injection directly into the knee joint. It is designed for the treatment of osteoarthritis of the knee in patients who have not responded adequately to conservative non-pharmacologic therapies and simple analgesics. The medication supplements the synovial fluid in the joint to help restore lubrication and cushioning.
Euflexxa is an injectable hyaluronic acid viscosupplement used to treat knee osteoarthritis by supplementing joint fluid.
Key facts at a glance
- RxNorm
- 604726
- Generic
- Euflexxa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Euflexxa is indicated for the treatment of osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy (such as physical therapy and weight loss) and simple analgesics like acetaminophen.
Euflexxa contains sodium hyaluronate, a naturally occurring component of synovial fluid. In osteoarthritis, the concentration and molecular weight of hyaluronic acid in the joint decreases, leading to reduced joint lubrication and cushioning. Euflexxa supplements the synovial fluid to restore viscoelastic properties, helping to lubricate the joint and absorb shock during movement.
Euflexxa is administered as a series of intra-articular injections directly into the knee joint by a healthcare professional. It is contraindicated in patients with known hypersensitivity to hyaluronate products or gram-positive bacterial proteins. Temporary pain, swelling, or stiffness at the injection site may occur. Safety in pregnant women, nursing mothers, and children has not been established.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy