Evamist
Evamist is a topical estrogen replacement therapy spray containing estradiol that is applied to the skin. It is primarily prescribed to treat moderate to severe symptoms of menopause, including hot flashes and vaginal symptoms, and may also be used to prevent postmenopausal osteoporosis. This medication delivers estrogen directly through the skin for systemic hormonal replacement.
Evamist is a brand-name estradiol spray used for estrogen replacement therapy to manage menopause symptoms.
Key facts at a glance
- RxNorm
- 728119
- Generic
- Evamist
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Evamist is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, such as hot flashes and night sweats. It may also help with menopausal changes in the vagina (vaginal atrophy) and is sometimes prescribed to help prevent osteoporosis after menopause in women who cannot take other medications for this condition.
Evamist contains estradiol, a synthetic form of the primary female sex hormone estrogen. When applied to the skin as a spray, estradiol is absorbed into the bloodstream to replace the estrogen that the ovaries produce less of during menopause, thereby helping to reduce menopausal symptoms.
Evamist should be applied to clean, dry skin on the inner forearm. Contact with others (especially children and partners) should be avoided after application until the spray has dried. Women with a history of certain cancers, blood clots, heart attack, or stroke should not use this medication. Regular follow-up with a healthcare provider is important while using hormone replacement therapy to monitor for potential side effects and reassess ongoing need for treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy