Everolimus
Everolimus is an mTOR inhibitor used to treat certain cancers and tuberous sclerosis complex (TSC). It works by blocking the mTOR pathway, which is abnormally active in these conditions, helping to slow or stop abnormal cell growth and shrink tumors.
Everolimus is an mTOR inhibitor used to treat certain cancers and tuberous sclerosis complex by blocking a key pathway involved in abnormal cell growth.
Key facts at a glance
- ATC
- L01EG02
- RxNorm
- 141704
- Generic
- Everolimus
- Class
- atc-l01
- Brands
- Torpenz, Yulithira, Afinitor, Zortress
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Everolimus is used to treat various cancers including renal cell carcinoma, breast cancer, neuroendocrine tumors, and tuberous sclerosis complex (TSC), a genetic disorder characterized by benign tumors in multiple organs.
Everolimus binds to an intracellular protein (FKBP-12) and inhibits the mammalian target of rapamycin (mTOR), a key serine-threonine kinase downstream of the PI3K/AKT pathway. By blocking this pathway, it prevents abnormal cell proliferation and tumor growth.
Everolimus may cause immunosuppression, mouth sores, rash, and metabolic side effects. Patients should be monitored for infections and blood counts. It is typically used under specialist supervision and may interact with other medications that affect the CYP3A4 pathway.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy