Evkeeza
Evkeeza (evinacumab) is a prescription brand-name medication used to treat homozygous familial hypercholesterolemia (HoFH), a serious genetic condition causing severely high cholesterol levels, in patients 12 years and older. It works by inhibiting ANGPTL3, a protein that regulates lipid metabolism, thereby lowering LDL (bad) cholesterol and other harmful lipids when used alongside other cholesterol-lowering therapies.
Evkeeza is an ANGPTL3 inhibitor monoclonal antibody used to treat dangerously high cholesterol in patients with homozygous familial hypercholesterolemia.
Key facts at a glance
- RxNorm
- 2478462
- Generic
- Evkeeza
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Evkeeza is indicated as an adjunct to other low-density lipoprotein-cholesterol (LDL-C) lowering therapies for the treatment of adult and pediatric patients 12 years of age and older with homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder causing extremely elevated LDL cholesterol from birth.
Evkeeza is a monoclonal antibody that binds to and inhibits angiopoietin-like 3 (ANGPTL3), a protein that normally inhibits lipoprotein lipase and endothelial lipase. By blocking ANGPTL3, Evkeeza increases the breakdown of triglycerides and reduces LDL cholesterol and apolipoprotein B levels, independent of LDL receptor activity.
Evkeeza is administered as an intravenous infusion every 4 weeks. Common side effects may include nasopharyngitis, influenza-like illness, dizziness, back pain, and nausea. Patients should be monitored for allergic reactions during infusion. It should be used in conjunction with a low-fat diet and other lipid-lowering therapies. Pregnancy and breastfeeding safety information should be discussed with a healthcare provider.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy