Exemestane
Exemestane is an aromatase inhibitor used to treat hormone receptor-positive breast cancer in postmenopausal women. It works by blocking the aromatase enzyme, which converts androgens to estrogens, thereby reducing estrogen levels that can fuel breast cancer growth. It is typically used as adjuvant therapy after surgery or when other hormonal treatments have proven insufficient.
Exemestane is an aromatase inhibitor used to treat hormone receptor-positive breast cancer in postmenopausal women by reducing estrogen production.
Key facts at a glance
- ATC
- L02BG06
- RxNorm
- 258494
- Generic
- Exemestane
- Class
- atc-l02
- Brands
- Aromasin
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of hormone receptor-positive early or advanced breast cancer in postmenopausal women. Often used as adjuvant therapy following treatment with tamoxifen or when other hormonal therapies have not worked.
Exemestane irreversibly inhibits aromatase, the enzyme responsible for converting androgens to estrogens. In postmenopausal women, aromatase in fat tissue and other sites becomes the primary source of estrogen production, so blocking this enzyme significantly reduces circulating estrogen levels.
Only indicated for postmenopausal women. Common side effects include hot flashes, joint pain, fatigue, and bone density loss (osteoporosis risk). May increase fracture risk. Not for use during pregnancy. Should not be used concurrently with tamoxifen or estrogen-containing therapies.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy