Exkivity
Exkivity (mobocertinib) is a prescription oral medication classified as a tyrosine kinase inhibitor (TKI). It was specifically developed for adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumors have EGFR exon 20 insertion mutations. The medication works by targeting and inhibiting specific proteins that promote cancer cell growth.
Exkivity was a targeted therapy for a specific type of lung cancer with EGFR exon 20 insertion mutations.
Key facts at a glance
- RxNorm
- 2570743
- Generic
- Exkivity
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Exkivity was indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations, as detected by an FDA-approved test, who have received prior platinum-based chemotherapy.
Exkivity is a tyrosine kinase inhibitor that works by blocking the activity of EGFR (epidermal growth factor receptor) with exon 20 insertion mutations. By inhibiting these specific mutations, the medication helps slow or stop the growth of cancer cells.
Exkivity has been associated with serious side effects including QT prolongation and cardiac toxicity. Patients should be monitored for heart rhythm changes and肺部 side effects. The medication was discontinued globally by the manufacturer in 2024.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy