Ezogabine
Ezogabine is an antiepileptic medication primarily used as add-on therapy for adults with partial-onset seizures. It works by activating potassium channels in the brain, helping to stabilize neuronal electrical activity and reduce seizure frequency.
Ezogabine is an adjunctive treatment for partial-onset seizures that works by opening potassium channels to reduce abnormal brain activity.
Key facts at a glance
- ATC
- N03AX21
- RxNorm
- 1112990
- Generic
- Ezogabine
- Class
- atc-n03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Adjunctive treatment of partial-onset seizures in adults with epilepsy who are not adequately controlled with other antiepileptic medications.
Ezogabine activates voltage-gated potassium channels (specifically KCNQ2-5 channels), which helps stabilize neuronal membranes and reduces the repetitive firing of neurons that leads to seizure activity.
May cause urinary retention, QT prolongation, and neurological effects such as dizziness and somnolence. Has been associated with blue skin discoloration with prolonged use. Should be used with caution in patients with a history of urinary retention or cardiac conduction abnormalities.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy