Factor VIIa
Factor VIIa is a recombinant clotting factor used to treat and prevent bleeding episodes in patients with hemophilia A or B who have developed inhibitors to standard factor replacement therapy, as well as in acquired hemophilia and congenital Factor VII deficiency. It works by directly activating the coagulation cascade, bypassing the need for Factors VIII or IX.
A recombinant clotting factor that treats bleeding in hemophilia patients with inhibitors by directly activating the coagulation cascade.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- B02BD08
- RxNorm
- 4256
- Generic
- Factor Viia
- Class
- atc-b02
- Brands
- Novoseven, Sevenfact
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of bleeding episodes in hemophilia A or B with inhibitors, acquired hemophilia, congenital Factor VII deficiency, and Glanzmann's thrombasthenia when platelet transfusion is not effective.
Recombinant Factor VIIa binds to tissue factor in the presence of calcium and phospholipids, directly activating Factor X to Factor Xa, effectively bypassing the intrinsic coagulation pathway.
Administered intravenously; carries risk of thrombotic events including venous thrombosis, arterial thrombosis, and DIC. Should be used only when clinically indicated. Not interchangeable with other hemostatic agents. Monitor for signs of thrombosis during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy