Factor XIII
Factor XIII is a coagulation factor replacement therapy used to prevent and treat bleeding in patients with congenital Factor XIII deficiency. It works by stabilizing blood clots through cross-linking of fibrin, which helps maintain clot integrity. This medication is typically administered by intravenous injection in clinical settings.
Factor XIII replacement therapy is used to treat bleeding in patients with Factor XIII deficiency by stabilizing blood clots.
Key facts at a glance
- ATC
- B02BD07
- RxNorm
- 4271
- Generic
- Factor Xiii
- Class
- atc-b02
- Brands
- Corifact, Tretten
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Congenital Factor XIII deficiency (a rare inherited bleeding disorder), acquired Factor XIII deficiency, and adjunctive therapy to improve hemostasis during surgical procedures.
Factor XIII (fibrin-stabilizing factor) is activated by thrombin and calcium, then cross-links fibrin molecules to form stable, durable clots that resist premature breakdown.
Available as plasma-derived or recombinant formulations. Regular prophylactic dosing may be required for patients with complete Factor XIII deficiency. Monitoring of Factor XIII levels helps guide dosing. Should be used under medical supervision with appropriate laboratory testing.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy