Fexinidazole
Fexinidazole is an antiprotozoal medication developed to treat Human African Trypanosomiasis (HAT), commonly known as African sleeping sickness, caused by Trypanosoma brucei gambiense. It represents a significant advancement as the first oral treatment for this neglected tropical disease, offering an alternative to previous medications that required complex administration. The drug is typically used in the early to intermediate stages of the disease.
Fexinidazole is an oral antiprotozoal medication used to treat African sleeping sickness (Human African Trypanosomiasis).
Key facts at a glance
- ATC
- P01CA03
- RxNorm
- 2564146
- Generic
- Fexinidazole
- Class
- atc-p01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Fexinidazole is indicated for the treatment of Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense, covering both early and intermediate (meningoencephalitic) stages of the disease.
As a nitroimidazole prodrug, Fexinidazole is metabolized to its active form inside trypanosome parasites, where it causes DNA strand breakage and disrupts cellular function, ultimately leading to parasite death.
Fexinidazole is administered orally, making it more accessible for use in endemic regions compared to older therapies requiring injections. Patients should complete the full course of treatment. Common side effects may include gastrointestinal symptoms, headache, and rash. It is contraindicated in patients with severe hepatic or renal impairment and should be used with caution during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy