Fezolinetant
Fezolinetant (VEOZAH) is a prescription medication used to treat moderate to severe vasomotor symptoms, commonly known as hot flashes, associated with menopause. It works by blocking neurokinin 3 (NK3) receptors in the brain, which helps reduce the frequency and severity of hot flashes. This medication offers a non-hormonal treatment option for women who cannot or prefer not to use hormone therapy.
Fezolinetant is a non-hormonal medication that reduces hot flashes during menopause by blocking NK3 receptors in the brain's thermoregulatory system.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G02CX06
- RxNorm
- 2637134
- Generic
- Fezolinetant
- Class
- atc-g02
- Brands
- Veozah
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Fezolinetant is indicated for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause, including hot flashes and night sweats.
Fezolinetant is a neurokinin 3 (NK3) receptor antagonist that blocks neurokinin B (NKB) from binding to KNDy neurons in the thermoregulatory center of the hypothalamus, modulating neuronal activity and reducing hot flash occurrence.
This is a non-hormonal therapy, making it suitable for women who cannot use hormone replacement therapy. Liver function monitoring may be required during treatment. Common side effects may include abdominal pain and abnormal liver function tests.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy