Fidaxomicin
Fidaxomicin is a narrow-spectrum macrolide antibiotic used to treat Clostridioides difficile infections, working by inhibiting bacterial RNA polymerase.
Fidaxomicin is an antibiotic specifically used to treat C. difficile infections, a common cause of severe antibiotic-associated diarrhea.
Key facts at a glance
- ATC
- A07AA12
- RxNorm
- 1111103
- Generic
- Fidaxomicin
- Class
- atc-a07
- Brands
- Dificid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of Clostridioides difficile infection (CDI), including initial episodes and recurrence prevention. It is specifically indicated for diarrhea caused by C. difficile bacteria.
Fidaxomicin inhibits bacterial RNA polymerase, blocking bacterial transcription and RNA synthesis. It has a narrow spectrum of activity focused on gram-positive bacteria, particularly C. difficile, with minimal absorption into the bloodstream, allowing it to act primarily in the gastrointestinal tract.
Take with or without food as directed by your physician. Complete the full course of treatment even if symptoms improve. Common side effects may include nausea, vomiting, and abdominal pain. Inform your doctor if you are pregnant, breastfeeding, or have any known allergies before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy